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Organocatalyzed Asymmetric Friedel-Crafts Reactions of Aromatic Heterocycles with 5-methylene Melldrum's Acid Derivatives. New Synthetic method of Biological and Pharmaceutical Interesting Moieties
Celem projektu jest opracowanie asymetrycznej metody syntezy związków o znaczeniu biologicznym przy użyciu chiralnych związków chemicznych jako organokatalizatorów w reakcji.
Details
- Project's acronym:
- 0091
- Financial Program Name:
- Innowacyjna Gospodarka
- Organization:
- Fundacja na Rzecz Nauki Polskiej (Foundation for Polish Science)
- Agreement:
- POMOST/2013-8/6 z dnia 2014-07-21
- Realisation period:
- 2014-06-01 - 2015-12-31
- Project manager:
- dr inż. Karolina Janikowska
- Realised in:
- Faculty of Chemistry
- Project's value:
- 221 000.00 PLN
- Request type:
- European Founds
- Domestic:
- Domestic project
- Verified by:
- Gdańsk University of Technology
Papers associated with that project
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Catalog Projects
Year 2018
-
Stereoselective Alkylation of Indole with 5-Arylidene-Meldrum’s Acids in the Presence of Organocatalysts
PublicationBackground: Indole motif is frequently present in biologically active compounds. Enantiomerically pure or enriched 2,2-dimethyl-5-(aryl(1H-indol-3-yl)methyl)-1,3-dioxane-4,6-diones can be considered as a convenient starting point for the synthesis of a indole ring fused with cyclic ketones with biological activity. Preparation of chiral 2,2-dimethyl-5-(aryl(1H-indol-3-yl)methyl)-1,3-dioxane- 4,6-diones requires the reaction of...
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