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The main goal of the research project is to develop a multilayer and dynamic model of a skin substitute using two connected robots capable of creating tissue systems with a network of transport vessels containing a nutrient medium for cells placed in alternating layers, with a composition similar to the extracellular matrix (ECM). The model will be created on the basis of a chitosan-agarose composite doped with collagen proteins and/or QHREDGS peptide in free form or covalently bound to chitosan using maleimidoglycine as an efficient and mild cross-linking agent. The pioneering research of the consortium members will be used in the development of a universal multilayer skin regenerative model, in which the multiplication and differentiation of cells and the biodegradation of the scaffold already populated by cells can take place independently during the culture. It is the only non-commercial model adapted to hydrogel materials characterized by a fast phase transition in the cell-safe temperature range, and the only model that, thanks to the use of knowledge and new technologies, will allow to get
as close as possible to the skin model as a new analytical tool.
Current scientific works do not indicate the possibility of using the above materials together with the proposed technology of their processing. Both the method of preparation of biocompatible chitosan hydrogel (PG), its composite with agarose, composition and application (PG and MUG) and the use of maleimidoglycine in polymer coupling (UG) are pioneering research of the team, which are the subject of granted patents (PL 223280, PL 222739, EP 2920240) or are in the final stage of filing an invention. Thus, the combination of the competences of the consortium members and their achievements to date has a chance to initiate a new path of research in the field of skin tissue regeneration, especially the one burdened with disease.
Details
- Financial Program Name:
- OPUS
- Organization:
- Narodowe Centrum Nauki (NCN) (National Science Centre)
- Realisation period:
- unknown - unknown
- Project manager:
- dr inż. Szymon Mania
- Realised in:
- Department of Chemistry, Technology and Biotechnology of Food
- External institutions
participating in project: -
- Uniwersytet Gdański (Poland)
- Gdański Uniwersytet Medycczny (Poland)
- Request type:
- National Research Programmes
- Domestic:
- Domestic project
- Verified by:
- Gdańsk University of Technology
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