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Abstract
Oxidative stress is believed to play a critical role in atherosclerosis initiation and progression. In line with this, in a group of 1099 subjects, we determined eight single nucleotide polymorphisms (SNPs) related to oxidative stress (PON1 c.575A>G, MPO c.463G>A, SOD2 c.47T>C, GCLM c.590C>T, NOS3 c.894G>T, NOS3 c.786T>C, CYBA c.214C>T, and CYBA c.932A>G) and assessed the extent of atherosclerosis in coronary arteries based on Gensini score. An increased risk of having a Gensini score in the higher half of the distribution was observed for the PON1 c.575G allele (odds ratio (OR) = 1.27, 95% confidence interval (CI): 1.004–1.617, p = 0.046). Next, the genetic risk score (GRS) for the additive eect of the total number of pro-oxidative alleles was assessed. We noted an increase in the risk of having a Gensini score above the median with the maximum number of risk alleles (OR = 2.47, 95% CI: 1.19–5.23, p = 0.014). A univariate Spearman’s test revealed significant correlation between the total number of pro-oxidant alleles (GRS) and the Gensini score ( = 0.068, p = 0.03). In conclusion, the PON1 c.575A>G variant and the high number of risk alleles (GRS) were independent risk factors for a high Gensini score. We suggest, however, that GRS might occur as a more valuable component in adding a predictive value to the genetic background of atherosclerosis.
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Authors (9)
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Milena Racis
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Wojciech Sobiczewski
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Marcin Wirtwein
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Natalia Krawczyńska
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Janusz Limon Prof. dr hab.
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Andrzej Rynkiewicz
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Marcin Gruchała
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Full text
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/life10090210
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
Life
no. 10,
ISSN: 0024-3019 - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Racis M., Stanisławska-Sachadyn A., Sobiczewski W., Wirtwein M., Krzemiński M., Krawczyńska N., Limon J., Rynkiewicz A., Gruchała M.: Association of Genes Related to Oxidative Stress with the Extent of Coronary Atherosclerosis// Life -Vol. 10,iss. 9 (2020), s.210-
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/life10090210
- Verified by:
- Gdańsk University of Technology
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