Search
Carotid Artery Stenting and Blood–Brain Barrier Permeability in Subjects with Chronic Carotid Artery Stenosis
Abstract
Failure of the blood-brain barrier (BBB) is a critical event in the development and progression of diseases such as acute ischemic stroke, chronic ischemia or small vessels disease that affect the central nervous system. It is not known whether BBB breakdown in subjects with chronic carotid artery stenosis can be restrained with postoperative recovery of cerebral perfusion. The aim of the study was to assess the short-term effect of internal carotid artery stenting on basic perfusion parameters and permeability surface area-product (PS) in such a population. Forty subjects (23 males) with stenosis of >70% within a single internal carotid artery and neurological symptoms who underwent a carotid artery stenting procedure were investigated. Differences in the following computed tomography perfusion (CTP) parameters were compared before and after surgery: global cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP) and PS. PS acquired by CTP is used to measure the permeability of the BBB to contrast material. In all baseline cases, the CBF and CBV values were low, while MTT and TTP were high on both the ipsi- and contralateral sides compared to reference values. PS was approximately twice the normal value. CBF was higher (+6.14%), while MTT was lower (−9.34%) on the contralateral than on the ipsilateral side. All perfusion parameters improved after stenting on both the ipsilateral (CBF +22.66%; CBV +18.98%; MTT −16.09%, TTP −7.62%) and contralateral (CBF +22.27%, CBV +19.72%, MTT −14.65%, TTP −7.46%) sides. PS decreased by almost half: ipsilateral −48.11%, contralateral −45.19%. The decline in BBB permeability was symmetrical on the ipsi- and contralateral sides to the stenosis. Augmented BBB permeability can be controlled by surgical intervention in humans.
Citations
-
1 0
CrossRef
-
0
Web of Science
-
1 6
Scopus
Authors (8)
-
Arkadiusz Szarmach
-
Grzegorz Halena
-
Maciej Piskunowicz
-
Michal Studniarek
-
Piotr Lass
-
Edyta Szurowska
-
Pawel Winklewski
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ijms18051008
- License
-
open in new tab
Keywords
Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
no. 18,
edition 5,
pages 1 - 14,
ISSN: 1661-6596 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Szarmach A., Halena G., Kaszubowski M. F., Piskunowicz M., Studniarek M., Lass P., Szurowska E., Winklewski P.: Carotid Artery Stenting and Blood–Brain Barrier Permeability in Subjects with Chronic Carotid Artery Stenosis// INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. -Vol. 18, iss. 5 (2017), s.1-14
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ijms18051008
- Verified by:
- Gdańsk University of Technology
seen 82 times
Recommended for you
Perfusion computed tomography: 4 cmversus8 cm coverage size in subjects with chronic carotid artery stenosis
- A. Szarmach,
- G. Halena,
- M. F. Kaszubowski
- + 4 authors
Computed tomography indicators of cerebral microperfusion improve long term after carotid stenting in symptomatic patients
- P. J. Winklewski,
- M. Kaszubowski,
- G. Halena
- + 7 authors
Regional resting state perfusion variability and delayed cerebrovascular uniform reactivity in subjects with chronic carotid artery stenosis
- A. Szarmach,
- M. F. Kaszubowski,
- A. Sabisz
- + 7 authors
Morphometric evaluation of the delayed cerebral arteries response to acetazolamide test in patients with chronic carotid artery stenosis using computed tomography angiography
- A. Szarmach,
- P. J. Winklewski,
- G. Halena
- + 5 authors