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Abstract
Potential antimicrobial agents may be effective if they are delivered efficiently to their site of action. In many cases, lack of permeability through the cell membrane is the main problem. One of the possible solutions could be a novel intracellular delivery system involving cell-penetrating peptides (CPPs), which may improve the efficiency of many new biophar-maceuticals. Among other things, CPPs are capable of trans-porting molecules that vary in structure and size such as: small molecules, RNA and DNA nucleotides, nanoparticles, peptides, proteins and even liposomes. CPP-cargo conjugates are inter-nalised by endocytosis and other mechanisms of intracellular de-livery not involving any receptors and not causing any signifi-cant cell membrane damage. Due to their relatively small size, CPPs are relatively easy to synthesize using the solid phase-based methodology..
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Keywords
Details
- Category:
- Monographic publication
- Type:
- rozdział, artykuł w książce - dziele zbiorowym /podręczniku w języku o zasięgu międzynarodowym
- Title of issue:
- PhD Interdisciplinary Journal. No. 1 strony 31 - 36
- Language:
- English
- Publication year:
- 2013
- Bibliographic description:
- Kawczyński M.: Cell-penetrating peptides – mechanism of transduction and synthesis – short review// PhD Interdisciplinary Journal. No. 1/ ed. M. Czubenko Gdańsk: Gdańsk University of Technology, 2013, s.31-36
- Verified by:
- Gdańsk University of Technology
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