Design, synthesis, and molecular docking of new 5-HT reuptake inhibitors based on modified 1,2-dihydrocyclopenta[b] indol-3(4H)-one scaffold - Publication - Bridge of Knowledge

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Design, synthesis, and molecular docking of new 5-HT reuptake inhibitors based on modified 1,2-dihydrocyclopenta[b] indol-3(4H)-one scaffold

Abstract

A new group of serotonin reuptake inhibitors containing 1,2-dihydrocyclopenta[b]indol-3(4H)-one scaffoldwas synthesized, starting from indole 5-((1H-indol-3-yl)(1,3-dioxane-4,6-diones as a key intermediates. Following three transformations including intramolecular cyclization and formation of imines, a series of new ligand for human serotonin transporter was obtained. The ability of these ligands to inhibit human TS3 serotonin transporter as well as selectivity toward human D3 dopamine receptor and dopamine transporter were tested in silico using docking software.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
JOURNAL OF CHEMICAL SCIENCES no. 131, pages 1 - 13,
ISSN: 0974-3626
Language:
English
Publication year:
2019
Bibliographic description:
Szewczyk M., Punda P., Janikowska K., Makowiec S.: Design, synthesis, and molecular docking of new 5-HT reuptake inhibitors based on modified 1,2-dihydrocyclopenta[b] indol-3(4H)-one scaffold// JOURNAL OF CHEMICAL SCIENCES -Vol. 131,iss. 6 (2019), s.1-13
DOI:
Digital Object Identifier (open in new tab) 10.1007/s12039-019-1621-x
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