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Precision Multi-Band Terahertz Metamaterial Biosensor with Targeted Spectral Selectivity for Early Detection of MCF-7 Breast Cancer Cells
Abstract
This study introduces a novel multi-band metamaterial (MTM)-based biosensor specifically designed for the detection of MCF-7 breast cancer cells. The sensor features a compact geometry composed of multiple resonators made from 200-nm-thick aluminum (Al) layers on a 50-μm-thick polyethylene terephthalate (PET) substrate. With dimensions of only 198 × 198 μm², the proposed device is exceptionally compact. It operates in the 0.5 THz to 1.6 THz frequency range and achieves near-perfect absorption rates (>99%) across multiple bandwidths. These results are achieved through precise tuning of the sensor's geometry and architectural optimization, significantly enhancing its sensitivity for cancer detection. Comprehensive validation of the sensor is performed using full-wave electromagnetic analysis, which includes evaluating electric and magnetic field distributions, surface currents, and scattering parameters. Extensive benchmarking demonstrates the device’s superior performance compared to state-of-the-art biosensors, excelling in metrics such as quality-factor, figure of merit (FOM), and absorption efficiency. Additionally, the proposed sensor has been integrated into an MWI system to evaluate its practical application. The device successfully discriminated against subtle changes in the refractive index of biological tissues, confirming its ability to detect MCF-7 cells effectively. These findings highlight the sensor's suitability as a non-invasive, early-stage diagnostic tool for breast cancer.
Citations
Authors (13)
-
Musa N. Hamza
-
Mohammad Alibakhshikenari
-
Bal Virdee
-
Sunil Lavadiva
-
Iftikhar Din Un
-
Bruno Sanches
-
Seyda Iffat Naqvi
-
Abinash Panda
-
Ali Farmani
-
Salahudin Khan
-
Lida Kouhalvandi
-
Milad Shariatifar
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Details
- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
-
IEEE SENSORS JOURNAL
no. 25,
pages 14970 - 14987,
ISSN: 1530-437X - Language:
- English
- Publication year:
- 2025
- Bibliographic description:
- Hamza M. N., Alibakhshikenari M., Virdee B., Lavadiva S., Din Un I., Sanches B., Kozieł S., Naqvi S. I., Panda A., Farmani A., Khan S., Kouhalvandi L., Shariatifar M.: Precision Multi-Band Terahertz Metamaterial Biosensor with Targeted Spectral Selectivity for Early Detection of MCF-7 Breast Cancer Cells// IEEE SENSORS JOURNAL -Vol. 25,iss. 9 (2025), s.14970-14987
- DOI:
- Digital Object Identifier (open in new tab) 10.1109/jsen.2025.3545789
- Sources of funding:
-
- Free publication
- Verified by:
- Gdańsk University of Technology
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