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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects

Abstract

Skin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose of identifying proteins and small molecules involved in the pathogenesis and development of the disease. This review discusses proteomics and metabolomics strategies and their utility in research and clinical practice in psoriasis and psoriasis arthritis. We summarize the studies, from in vivo models conducted on animals through academic research to clinical trials, and highlight their contribution to the discovery of biomarkers and targets for biological drugs.

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DOI:
Digital Object Identifier (open in new tab) 10.3390/ijms24119507
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Creative Commons: CC-BY open in new tab

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES no. 24,
ISSN: 1661-6596
Language:
English
Publication year:
2023
Bibliographic description:
Radulska A., Pelikant-Malecka I., Jendernalik K., Dobrucki I. T., Kalinowski L.: Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects// INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -Vol. 24,iss. 11 (2023), s.9507-
DOI:
Digital Object Identifier (open in new tab) 10.3390/ijms24119507
Sources of funding:
  • This research was funded by the Polish Ministry of Education and Science, grants no. DIR/WK/2017/01 and 10/E-389/SPUB/SP/2020.
Verified by:
Gdańsk University of Technology

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