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Synthesis, Characterization and Biological Investigations of Half-Sandwich Ruthenium(II) Complexes Containing Benzimidazole Moiety
Abstract
Half-sandwich Ru(II) complexes belong to group of biologically active metallo-compounds with promising antimicrobial and anticancer activity. Herein, we report the synthesis and characteri- zation of arene ruthenium complexes containing benzimidazole moiety, namely, [(η6-p-cymene)RuC l(bimCOO)] (1) and [(η6-p-cymene)RuCl2(bim)] (2) (where bimCOO = benzimidazole-2-carboxylate and bim = 1-H-benzimidazole). The compounds were characterized by 1H NMR, 13C NMR, IR, UV–vis and CV. Molecular structures of the complexes were determined by SC-XRD analysis, and the results indicated the presence of a pseudo-tetrahedral (piano stool) geometry. Interactions in the crystals of the Ru complexes using the Hirshfeld surface analysis were also examined. In addition, the biological studies of the complexes, such as antimicrobial assays (against planktonic and adherent microbes), cytotoxicity and lipophilicity, were performed. Antibacterial activity of the complexes was evaluated against S. aureus, E. coli, P. aeruginosa PAO1 and LES B58. Cytotoxic activity was tested against primary human fibroblasts and adenocarcinoma human alveolar basal epithelial cells. Obtained biological results show that the ruthenium compounds have bacteriostatic activity toward Pseudomonas aeruginosa PAO1 strain and are not toxic to normal cells. A molecular docking study was applied as a predictive source of information about the plausibility of examined structures binding with HSA as a transporting system.
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Authors (9)
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Patrycja Rogala mgr
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Agnieszka Jabłońska-Wawrzycka dr
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Grzegorz Czerwonka dr
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Katarzyna Gałczyńska
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Sławomir Michałkiewicz
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Justyna Kalinowska-Tłuścik
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Marta Karpiel
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Karel D. Klika
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/molecules28010040
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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MOLECULES
no. 28,
ISSN: 1420-3049 - Language:
- English
- Publication year:
- 2023
- Bibliographic description:
- Rogala P., Jabłońska-Wawrzycka A., Czerwonka G., Kazimierczuk K., Gałczyńska K., Michałkiewicz S., Kalinowska-Tłuścik J., Karpiel M., Klika K. D.: Synthesis, Characterization and Biological Investigations of Half-Sandwich Ruthenium(II) Complexes Containing Benzimidazole Moiety// MOLECULES -Vol. 28,iss. 1 (2023), s.40-
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/molecules28010040
- Sources of funding:
-
- opłata publikacyjna była pokryta z dwóch projektów badawczych SUPB.RN. .21.171. i SPB.RN. 21.176 (UJK)
- Verified by:
- Gdańsk University of Technology
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