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Synthesis, structure, DNA binding and anticancer activity of mixed ligand ruthenium(II) complex

Abstract

In order to obtain a potential chemotherapeutic which is not affected on the normal BALB/3T3 cell line, a new arene ruthenium(II) complex {[RuCl(L1)(η6-p-cymene)]PF6}2 · H2O has been synthesized by a direct reaction of precursor, [{(η6-p-cymene)Ru(μ-Cl)}2Cl2], with N,N-chelating ligand (L1 - 2,2′-bis(4,5-dimethylimidazole). The compound has been fully characterized by elemental analysis, X-ray diffraction, IR, UV–Vis and 1H, 13C NMR spectroscopies. X-ray analysis have confirmed that the compound crystallized in the monoclinic group Cc as an inversion twin. The asymmetric unit contains two symmetrically independent cationic complexes [RuCl(L1)(η6-p-cymene)]+ whose charge is balanced by two PF6− counterions. The shape of each cationic coordination polyhedral can be described as a distorted dodecahedron and shows a typical piano-stool geometry. In addition, an analysis of the crystal structure and the Hirshfeld surface analysis were used to detect and visualize important hydrogen bonds and intermolecular interaction. Moreover, the antiproliferative behavior of the obtained complex was assayed against three human cells: MV-4-11, LoVo, MCF-7 and BALB/3T3 - normal mice fibroblast cells. To predict a binding mode, a potential interaction of ruthenium complex with calf thymus DNA (CT-DNA) has been explored using UV absorption and circular dichroism (CD).

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Authors (6)

  • Photo of  Agnieszka Gilewska

    Agnieszka Gilewska

    • Institute of Chemistry, Jan Kochanowski University in Kielce
  • Photo of dr Joanna Masternak

    Joanna Masternak dr

    • Institute of Chemistry, Jan Kochanowski University in Kielce
  • Photo of  Trynda Justyna

    Trynda Justyna

    • Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
  • Photo of  Joanna Wietrzyk

    Joanna Wietrzyk

    • Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
  • Photo of dr hab. Barbara Barszcz

    Barbara Barszcz dr hab.

    • Institute of Chemistry, Jan Kochanowski University in Kielce

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Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
JOURNAL OF MOLECULAR STRUCTURE no. 1155, pages 288 - 296,
ISSN: 0022-2860
Language:
English
Publication year:
2018
Bibliographic description:
Gilewska A., Masternak J., Kazimierczuk K., Justyna T., Wietrzyk J., Barszcz B.: Synthesis, structure, DNA binding and anticancer activity of mixed ligand ruthenium(II) complex// JOURNAL OF MOLECULAR STRUCTURE. -Vol. 1155, (2018), s.288-296
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.molstruc.2017.10.105
Verified by:
Gdańsk University of Technology

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