Search results for: ENDOPLASMIC RETICULUM STRESS

• Endoplasmic Reticulum Stress in Diseases

  Journals

  ISSN: 2300-4266

• Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria

  Publication

  • D. Naón
  • M. I. Hernández-Alvarez
  • S. Shinjo
  • M. Wieczór
  • S. Ivanova
  • O. Martins de Brito
  • A. Quintana
  • J. Hidalgo
  • M. Palacín
  • P. Aparicio... and 9 others

  - SCIENCE - Year 2023

  In eukaryotic cells, different organelles interact at membrane contact sites stabilized by tethers. Mitochondrial mitofusin 2 (MFN2) acts as a membrane tether that interacts with an unknown partner on the endoplasmic reticulum (ER). In this work, we identified the MFN2 splice variant ERMIT2 as the ER tethering partner of MFN2. Splicing of MFN2 produced ERMIT2 and ERMIN2, two ER-specific variants. ERMIN2 regulated ER morphology,...

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• The Unfolded Protein Response: A Double-Edged Sword for Brain Health

  Publication

  • M. Gebert
  • J. Sławski
  • L. Kalinowski
  • J. F. Collawn
  • R. Bartoszewski

  - Antioxidants - Year 2023

  Efficient brain function requires as much as 20% of the total oxygen intake to support normal neuronal cell function. This level of oxygen usage, however, leads to the generation of free radicals, and thus can lead to oxidative stress and potentially to age-related cognitive decay and even neurodegenerative diseases. The regulation of this system requires a complex monitoring network to maintain proper oxygen homeostasis. Furthermore,...

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• Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor

  Publication

  • S. Bartoszewska
  • J. Króliczewski
  • D. Crossman
  • A. Pogorzelska
  • M. Bagiński
  • J. F. Collawn
  • R. Bartoszewski

  - CELLULAR & MOLECULAR BIOLOGY LETTERS - Year 2021

  Inositol requiring enzyme 1 alpha (IRE1α) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. During conditions of irrevocable stress, proapoptotic gene expression is induced to promote cell death. One of the three signaling stressors, IRE1α is an serine/threonine-protein kinase/endoribonuclease (RNase) that...

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• T cell Activation Is Driven by an ADP-Dependent Glukosinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation

  Publication

  • M. M. Kamiński
  • S. W. Sauer
  • M. A. Kamiński
  • S. Opp
  • T. Ruppert
  • P. Grigaravicius
  • P. Grudnik
  • H. Grone
  • P. H. Krammer
  • K. Gulow

  - Cell Reports - Year 2012

  Mitochondria-originating reactive oxygen species control T cell receptor (TCR)-induced gene expression. Here, we show that TCR-triggered activation of ADP-dependent glucokinase (ADPGK), an alternative, glycolytic enzyme typical for Archaea, mediates generation of the oxidative signal. We also show that ADPGK is localized in the endoplasmic reticulum and suggest that its active site protrudes toward the cytosol. The ADPGK-driven...

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• Development of Safirinium dyes for new applications: fluorescent staining of bacteria, human kidney cells, and the horny layer of the epidermis

  Publication

  • J. Fedorowicz
  • D. Bazar
  • W. Brankiewicz
  • H. Kapica
  • K. Ciura
  • B. Zalewska-Piątek
  • R. Piątek
  • K. Cal
  • K. Mojsiewicz-pieńkowska
  • J. Sączewski

  - Scientific Reports - Year 2022

  Low-molecular synthetic fluorophores are convenient tools in bioimaging applications. Several derivatives of Safirinium dyes as well as their reactive N-hydroxysuccinimide (NHS) esters bearing diverse substituents were synthesized and evaluated experimentally in terms of their lipophilicity by means of reverse-phase and immobilized artificial membrane high-performance liquid chromatography. Subsequently, the selected compounds...

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• Stress: The International Journal on the Biology of Stress

  Journals

  ISSN: 1025-3890 , eISSN: 1607-8888

• WORK AND STRESS

  Journals

  ISSN: 0267-8373 , eISSN: 1464-5335

• Neurobiology of Stress

  Journals

  ISSN: 2352-2895

• Cell Stress

  Journals

  eISSN: 2523-0204