Search results for: CHINESE HAMSTER OVARY CELLS

• Protein overproduction alters exosome secretion in Chinese hamster ovary cells

  Publication

  • A. Steć
  • M. Targońska
  • E. Karkosińska
  • M. Słowik
  • A. Płoska
  • L. Kalinowski
  • B. Wielgomas
  • K. Waleron
  • J. Jasiecki
  • S. Dziomba

  - ANALYTICAL AND BIOANALYTICAL CHEMISTRY - Year 2023

  Despite the abundance of available cell lines, nearly 70% of all recombinant therapeutic proteins today are produced in Chi-nese hamster ovary (CHO) cells. The impact of protein overproduction on the secretion of exosomes by CHO cells has been investigated here. Increased secretion of extracellular vesicles (EVs) by protein overexpressing CHO cells was demonstrated with protein content assay, nanoparticle tracking analysis, and...

  Full text available to download

• Analysis of cellular response induced by imidazoacridinone derivative C-1311 in Chinese hamster ovary carcinoma cells CHO with vorious expression level of cytochrome P450 reductase

  Publication

  • M. Demusiak
  • E. Augustin
  • T. Friedberg
  • Z. Mazerska

  - Acta Biochimica Polonica - Year 2009

  Rodzaj odpowiedzi komórkowej indukowanej przez pochodną C-1311 badany był w komórkach CHO o różnym poziomie reduktazy cytochromu P450. Wszystkie eksperymenty zostały przeprowadzone przy zastosowaniu stężenia związku odpowiadającego dawce EC80. Poziom ekspresji reduktazy cytochromu P450 nie miał istotnego wpływu na rodzaj odpowiedzi komórkowej indukowanej przez pochodną C-1311. Głównym efektem biologicznym wywieranym przez badany...

  Full text to download in external service

• The Interaction of Heptakis (2,6-di-O-Methyl)-β-Cyclodextrin with Mianserin Hydrochloride and Its Influence on the Drug Toxicity

  Publication

  • S. Belica-Pacha
  • M. Małecka
  • M. Daśko
  • K. Miłowska
  • M. Bryszewska
  • G. Budryn
  • J. Oracz
  • B. Pałecz

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2021

  One tetracyclic antidepressant, mianserin hydrochloride (MIA), has quite significant side effects on a patients’ health. Cyclodextrins, which are most commonly used to reduce the undesirable features of contained drugs within their hydrophobic interior, also have the potential to alter the toxic behavior of the drug. The present paper contains investigations and the characteristics of interaction mechanisms for MIA and the heptakis...

  Full text available to download

• Chromatographic analyses of Lavandula angustifolia and Rosmarinus officinalis extracts and their biological effects in mammalian cells and cell-free systems

  Publication

  • E. Horvathova
  • K. Kozicsa
  • M. Melusowa
  • E. Galova
  • A. Sevcovicowa
  • B. Kusznierewicz
  • T. Chmiel
  • D. Slamenova

  - NEOPLASMA - Year 2017

  Knowledge of biological properties of natural compounds allows to understand their therapeutic value, efficacy and security. We investigated: composition of Lavandula angustifolia (LA) and Rosmarinus officinalis (RO) extracts, their antioxidant capacity, cytotoxicity and genotoxicity, their DNA-protective potential against DNA damage induced in hamster V79 cells by several genotoxins or in plasmid DNA by Fe2+ ions and activity...

  Full text to download in external service

• Leydig cell tumor of ovary, NOS - Female, 50 - Tissue image [3300730005953701]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Granulosa cell tumor, adult type - Female, 49 - Tissue image [9230729557265341]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Granulosa cell tumor, adult type - Female, 49 - Tissue image [923072955726901]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Granulosa cell tumor, adult type - Female, 49 - Tissue image [9230729557264951]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Leydig cell tumor of ovary, NOS - Female, 50 - Tissue image [3300730006073831]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Granulosa cell tumor, adult type - Female, 49 - Tissue image [9230729557269271]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.