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Search results for: HEP
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METODA ANALIZY NIEZAWODNOŚCI CZŁOWIEKA SPAR-H W APLIKACJI ProSIL-EAL
PublicationW referacie przedstawiono zagadnienie wyznaczania prawdopodobieństwa błędu człowieka HEP za pomocą metody SPAR-H w oprogramowaniu ProSIL-EAL. Oprogramowanie wspomaga proces zarządzania bezpieczeństwem funkcjonalnym w cyklu życia systemów technicznych. Prawdopodobieństwo błędu człowieka jest zagadnieniem związanym z etapem weryfikacji określonych poziomów nienaruszalności bezpieczeństwa SIL dla funkcji bezpieczeństwa. ProSIL-EAL...
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Human Factors and Functional Safety Analysis in Designing the Control Rooms of Industrial Hazardous Plants
PublicationIn this work some aspects of human factors and functional safety analysis in designing the control rooms of industrial hazardous plants are presented. The “defence in depth” (D-in-D) concept is outlined. Some designing issues of the alarm system (AS) with regard to human factors to be supported using the human reliability analysis (HRA) are discussed. The AS and decision support system (DSS), when properly designed, would contribute...
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Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
PublicationHeterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...
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Molecular basis of lipopolysaccharide heterogeneity in Escherichia coli: envelope stress-responsive regulators control the incorporation of glycoforms with a third 3-deoxy-α-D-manno-oct-2-ulosonic acid and rhamnose.
PublicationMass spectrometric analyses of lipopolysaccharide (LPS) from isogenic Escherichia coli strains with nonpolar mutations in the waa locus or overexpression of their cognate genes revealed that waaZ and waaS are the structural genes required for the incorporation of the third 3-deoxy-α-D-manno-oct-2-ulosonic acid (Kdo) linked to Kdo disaccharide and rhamnose, respectively. The incorporation of rhamnose requires prior sequential incorporation...
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Exploring the technological dimension of Autonomous sensory meridian response-induced physiological responses
PublicationBackground In recent years, the scientific community has been captivated by the intriguing Autonomous sensory meridian response (ASMR), a unique phenomenon characterized by tingling sensations originating from the scalp and propagating down the spine. While anecdotal evidence suggests the therapeutic potential of ASMR, the field has witnessed a surge of scientific interest, particularly through the use of neuroimaging techniques...
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Analiza niezawodności człowieka z uwzględnieniem aspektów zarządzania alarmami
PublicationW artykule przedstawiono zagadnienie analizy warstwowego systemu zabezpieczeń z uwzględnieniem błędu człowieka-operatora. W analizie bezpieczeństwa funkcjonalnego systemów sterowania i zabezpieczeń istotną kwestią jest dokonanie redukcji ryzyka poprzez warstwy zabezpieczeniowo ochronne. W referacie przeanalizowano system składający się z trzech warstw: podstawowego systemu sterowania BPCS, systemu alarmowego AS oraz systemu automatyki...