Filters
total: 3652
filtered: 772
Search results for: LUNG AND COLON CANCER
-
Development of Sulfamoylated 4‑(1-Phenyl‑1H‑1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer
PublicationWe present here the advances achieved in the development of new sulfamoylated 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives as potent steroid sulfatase (STS) inhibitors for the treatment of breast cancer. Prompted by promising biological results and in silico analysis, the initial series of similar compounds were extended, appending a variety of m-substituents at the outer phenyl ring. The inhibition profiles of the newly...
-
Relationship between Telomere Length, TERT Genetic Variability and TERT, TP53, SP1, MYC Gene Co-Expression in the Clinicopathological Profile of Breast Cancer
PublicationThe molecular mechanisms of telomerase reverse transcriptase (TERT) upregulation in breast cancer (BC) are complex. We compared genetic variability within TERT and telomere length with the clinical data of patients with BC. Additionally, we assessed the expression of the TERT, MYC, TP53 and SP1 genes in BC patients and in BC organoids (3D cell cultures obtained from breast cancer tissues). We observed the same correlation in the...
-
The induction of autophagy in human colon wt p53 and p53-null HCT116 cells by 4-methyl-1-nitroacridine derivative C-1748
PublicationPrzeprowadzone badania miały na celu określenie zdolności pochodnej 4-metylo-1-nitroakrydyny C-1748 do uruchomienia autofagii komórek ludzkiego raka okrężnicy HCT116 posiadających dziki gen p53 oraz podlinii nie posiadającej tego genu. Wszystkie eksperymenty przeprowadzone zostały przy stężeniu hamującym proliferację komórek nowotworowych w 90%. Wykazano, że indukowana przez C-1748 autofagia w komórkach raka okrężnicy jest zależna...
-
The Effects of Single Nucleotide Polymorphisms in Cancer RNAi Therapies
Publication -
Coping strategies and sexual satisfaction in bladder cancer males
Publication -
Circadian Gene Polymorphisms Associated with Breast Cancer Susceptibility
Publication -
Novel Inhibitor-Based Therapies for Thyroid Cancer—An Update
Publication -
Single nucleotide polymorphisms associated with papillary thyroid cancer
Publication -
Probiotic Bacteria: A Promising Tool in Cancer Prevention and Therapy
Publication -
Recognition Dynamics of Cancer Mutations on the ERp57-Tapasin Interface
Publication -
High-grade serous ovarian cancer: the clone wars
Publication -
Molecular diagnosis in type I epithelial ovarian cancer
Publication -
Inhibitors of angiogenesis in cancer therapy – synthesis and biological activity
PublicationAngiogenesis is the process of formation of new capillaries from preexisting blood vessels. Angiogenesis is involved in normal physiological processes, and plays an important role in tumor invasion and development of metastases. Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis. VEGF is a mitogen for vascular endothelial cells and stimulates their proliferation. By inhibiting the biological activity of...
-
Neural network breast cancer relapse time prognosis
PublicationPrzedstawiono architekturę i wyniki testowania sztucznej sieci neuronowej w prognozowaniu czasu nawrotu choroby u kobiet chorych na raka piersi. Sieć neuronowa uczona była na danych zgromadzonych przez 20 lat. Dane opisują grupę 439 pacjentów za pomocą 40 parametrów. Spośród tych parametrów wybrano 6 najistotniejszych: liczbę przerzutowych węzłów chłonnych, wielkość guza, wiek, skalę według Blooma oraz stan receptorów estrogenowych...
-
Polymeric micelle-mediated delivery of half-sandwich ruthenium(II) complexes with phosphanes derived from fluoroloquinolones for lung adenocarcinoma treatment
Publication -
Cancer stem cells in drug resistance and drug screening: can we exploit the cancer stem cell paradigm in search for new antitumor agents?
PublicationPraca przedstawia przegląd literatury dotyczącej hipotezy komórek pierwotnych nowotworu, w szczególności w ich oporności na istniejące terapie. Dyskutowane jest także zagadnienie możliwości wykorzystania wiedzy o tych komórkach do konstrukcji nowych testów do badań przesiewowych in vitro w celu poszukiwania nowych leków przeciwnowotworowych.
-
Imidazoacridinone derivative C-1311 (SymadexTM) induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 status
PublicationPrzeprowadziliśmy badania zmierzające do wyjaśnienia odpowiedzi komórek ludzkiego raka jelita grubego HCT116 traktowanych C-1311 w zależności od statusu białka p53. Wykazaliśmy, że pochodna imidazoakrydonu C-1311 w stężeniach biologicznie istotnych indukuje przejściowy blok w fazie G2M komórek HCT116 p53-/- oraz blok w fazie G1 i G2M komórek HCT116 p53+/+. W komórkach z niefunkcjonalnym białkiem p53 imidazoakrydon indukował katastrofę...
-
The cellular response of human colon carcinoma HCT116 cells to 4-methyl-1-nitroacridine derivative C-1748 treatment depending on p53 status
PublicationWykazano, że pochodna C-1748 indukuje apoptozę w komórkach linii ludzkich raków jelita grubego HCT116 p53+/+ i p53-/- w sposób zależny od czasu inkubacji i stężenia związku. Wskazują na to: pojawienie się frakcji komórek sub-G1, charakterystyczne zmiany w morfologii jąder komórkowych, zmiany w strukturze błony plazmatycznej. Ponadto, pod wpływem badanego związku komórki HCT116 p53+/+ wykazują większą podatność do ulegania apoptozie...
-
Pro-apoptotic action of protein-carbohydrate fraction isolated from coelomic fluid of the earthworm Dendrobaena veneta against human colon adenocarcinoma cells
Publication -
Successive cytotoxicity control by evolutionary surface decorated electronic push-pull green ZnCr-LDH nanostructures: Drug delivery enlargement for targeted breast cancer chemotherapy
PublicationThe reason for the increasing bioavailability and biocompatibility of the porous nanomaterials in the presence of different (bio)molecules is still unknown. The role of difference functional groups and their interactions with the potential bioavailability and biocompatibility is of great importance. To investigate the potential contribution of the electronic effects (especially on the surface of the porous nanomaterials) on their...
-
Metabolic profiling of pteridines for determination of potential biomarkers in cancer diseases
Publication -
Comparison of Pteridine Normalization Methods in Urine for Detection of Bladder Cancer
Publication -
Nuclear quantum effects in a HIV/cancer inhibitor: The case of ellipticine
Publication -
Pemphigus foliaceus in a patient with skin cancer with metastases to lymph nodes
Publication -
Notch signalling pathway as an oncogenic factor involved in cancer development
Publication -
The role of Snail1 transcription factor in colorectal cancer progression and metastasis
Publication -
C-reactive Protein as a Diagnostic and Prognostic Factor of Endometrial Cancer
Publication -
The effects of RNA editing in cancer tissue at different stages in carcinogenesis
Publication -
Bladder cancer detection using a peptide substrate of the 20S proteasome
Publication -
Extracellular miRNAs as Biomarkers of Head and Neck Cancer Progression and Metastasis
Publication -
C-reactive protein as a diagnostic and prognostic factor of endometrial cancer
Publication -
The ICTBioMed NCIP Hub: Cancer research in a science gateway consortium
Publication -
Common variants of xeroderma pigmentosum genes and prostate cancer risk
Publication -
Sulforaphane inhibits growth of phenotypically different breast cancer cells
Publication -
The Role of miRNA-7 in the Biology of Cancer and Modulation of Drug Resistance
Publication -
Biological Effects of Cold Atmospheric Pressure Plasma on Skin Cancer
Publication -
The p53-mediated cytotoxicity of photodynamic therapy of cancer: Recent advances
Publication -
Clinical Relevance of Circulating Tumor Cells in Prostate Cancer Management
Publication -
VEGF – targeted therapy for the treatment of cervical cancer – literature review
Publication -
Safe-by-Design Ligand-Coated ZnO Nanocrystals Engineered by an Organometallic Approach: Unique Physicochemical Properties and Low Toxicity toward Lung Cells
Publication -
Extracellular matrix metalloproteinase inducer (EMMPRIN) expression correlates positively with active angiogenesis and negatively with basic fibroblast growth factor expression in epithelial ovarian cancer
Publication -
Urinary metabolomic signature of muscle-invasive bladder cancer: A multiplatform approach
Publication -
Quality of life in long-term survivors of early stage endometrial cancer
Publication -
Influence of Transurethral Resection of Bladder Cancer on Sexual Function, Anxiety, and Depression
Publication -
New data on antihypertensive drugs and risk of cancer: should we worry?
Publication -
Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer
Publication -
Prognostic factors in postoperative radiotherapy for prostate cancer – tertiary center experience
Publication -
Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines
Publication -
Cadmium, arsenic, selenium and iron– Implications for tumor progression in breast cancer
Publication -
Metachronous adenocarcinoma in a gastric tube after radical surgery for oesophageal cancer
Publication