Search results for: BICOUMARIN THIOPHOSPHATES

• Synthesis of bicoumarin thiophosphate derivatives as steroid sulfatase inhibitors

  Publication

  • S. Demkowicz
  • W. Kozak
  • M. Daśko
  • M. Masłyk
  • B. Gielniewski
  • J. Rachoń

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Year 2015

  Based on the frameworks of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy- 7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c] chromen-6-one, a series of bicoumarin thiophosphate analogs have been synthesized and biologically evaluated. Additionally, their binding modes have been modeled using docking techniques. The inhibitory properties of the synthesized compounds...

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