Search results for: NUCLEAR RECEPTORS

• Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells

  Publication

  • W. Liu
  • H. Cao
  • S. Liao
  • B. Kudłak
  • M. Williams
  • H. B. Schiöth

  - SCIENCE OF THE TOTAL ENVIRONMENT - Year 2021

  People are constantly exposed to phthalates, due to their common use in the production of plastics, pharmaceuticals, cosmetics and skin care products. The ability of phthalates to disrupt endocrine signaling, leading to developmental, reproductive and metabolic defects, has been studied, yet how phthalates interfere with these biological functions is still unclear. To uncover DBP interacting molecular pathways, we raised Drosophila...

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• New generation of analytical tests based on the assessment of enzymatic and nuclear receptor activity changes induced by environmental pollutants

  Publication

  • A. Bejrowska
  • B. Kudłak
  • K. Owczarek
  • N. Jatkowska
  • J. Namieśnik
  • Z. Mazerska

  - TRAC-TRENDS IN ANALYTICAL CHEMISTRY - Year 2015

  Analytical methods show great potential in biological tests. The analysis of biological response that results from environmental pollutant exposure allows: (i) prediction of the risk of toxic effects and (ii) provision of the background for the development of markers of the toxicants presence. Bioanalytical tests based on changes in enzymatic activity and nuclear receptor action provide extremely high specificity and sensitivity....

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