Search results for: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR

• Analysis of interactions responsible for vasopressin binding to human neurohypophyseal hormone receptors—molecular dynamics study of the activated receptor–vasopressin–Gα systems

  Publication

  • M. Ślusarz
  • A. Giełdoń
  • R. Ślusarz
  • J. Ciarkowski

  - JOURNAL OF PEPTIDE SCIENCE - Year 2006

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• Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse

  Publication

  • J. Podolak-Popinigis
  • B. Górnikiewicz
  • A. Ronowicz
  • P. Sachadyn

  - BMC GENOMICS - Year 2015

  Background: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...

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• Targeting of FLT3-ITD kinase contributes to high selectivity of imidazoacridinone C-1311 against FLT3-activated leukemia cells

  Publication

  • A. Skwarska
  • E. Augustin
  • M. Beffinger
  • A. Wojtczyk
  • S. Konicz
  • K. Laskowska
  • J. Polewska

  - BIOCHEMICAL PHARMACOLOGY - Year 2015

  Drugs targeting receptor tyrosine kinase FLT3 are of particular interest since activating FLT3-internal tandem duplication (ITD) mutations abundantly occur in fatal acute myeloid leukemias (AMLs). Imidazoacridinone C-1311, a DNA-reactive inhibitor of topoisomerase II, has been previously shown to be a potent and selective inhibitor of recombinant FLT3. Here, we expand those findings by studying its effect on leukemia cells with...

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