Search results for: P53

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021734471]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Oligodendroglioma, NOS - Unknown, 37 - Tissue image [329073001664881]

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  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024697901]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Aneurysmal bone cyst - Female, 14 - Tissue image [4270730007811321]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BONES, JOINTS AND ARTICULAR CARTILAGE OF LIMBS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Carcinoma, undifferentiated, NOS - Female, 45 - Tissue image [3220630024693081]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021714721]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021715301]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Red Kale (Brassica oleracea L. ssp. acephala L. var. sabellica) Induces Apoptosis in Human Colorectal Cancer Cells In Vitro

  Publication

  • K. Rachwał
  • I. Niedźwiedź
  • A. Waśko
  • T. Laskowski
  • P. Szczeblewski
  • W. Kukula-Koch
  • M. Polak-Berecka

  - MOLECULES - Year 2023

  This article presents the results of studies investigating the effect of red kale (Brassica oleracea L. ssp. acephala L. var. sabellica) extract on cancer cells (HT-29). The cytotoxicity of the red kale extract was assessed using MTT and LDH assays, while qRT-PCR was employed to analyze the expression of genes associated with the p53 signaling pathway to elucidate the effect of the extract on cancer cells. Furthermore, HPLC-ESI-QTOF-MS/MS...

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• Aneurysmal bone cyst - Female, 14 - Tissue image [4270730007816701]

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  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BONES, JOINTS AND ARTICULAR CARTILAGE OF LIMBS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Imidazoacridinone C-1311 induces both autophagy and senescence in human lung cancer A549 cells

  Publication

  • J. Polewska
  • A. Skwarska
  • E. Augustin
  • J. Konopa

  - Acta Biochimica Polonica - Year 2010

  Niedrobnokomórkowy rak płuc (ang. NSCLC, non-small cell lung cancer), stanowiący blisko 80-87% wszystkich przypadków, jest najczęściej występującą formą raka płuc. Skuteczność dotychczas stosowanych chemoterapeutyków w stosunku do tej formy raka jest bardzo ograniczona dlatego poszukuje się nowych związków o lepszych właściwościach leczniczych. Imidazoakrydon C-1311 wykazuje wysoką aktywność cytotoksyczną wobec komórek niedrobnokomórkowego...

• DNA-damaging imidazoacridinone C-1311 induces autophagy followed by irreversible growth arrest and senescence in human lung cancer cells

  Publication

  • J. Polewska
  • A. Skwarska
  • E. Augustin
  • J. Konopa

  - JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS - Year 2013

  Imidazoacridinone 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. In this study, we describe the unique sequence of cellular responses to C-1311 in human non-small cell lung cancer (NSCLC) cell lines, A549 and H460. In A549 cells, C-1311 (IC80 = 0.08 µM) induced G1 and G2/M arrests, whereas H460 cells (IC80 = 0.051 µM) accumulated...

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• Cross-talk between DNA damage and cell survival checkpoints during G2 and mitosis: pharmacological implications

  Publication

  • P. Bożko
  • M. Sabisz
  • A. K. Larsen
  • A. Składanowski

  - Year 2005

  W pracy wyjaśnialiśmy rolę surwiwiny w ochronie komórek w czasie przejścia między G2 i mitozą, traktowanych związkiem uszkadzającym DNA. Jako model komórkowy wybraliśmy komórki ludzkiej białaczki MOLT-4, które wykazują zwiększoną ekspresję białka surwiwiny i niefunkcjonalnym p53. Ekspozycja tych komórek na melfalan, klasyczny związek uszkadzający DNA, prowadzi do uruchomienia punktu kontrolnego w G2 i zablokowania progresji cyklu...

• Endometrioid adenocarcinoma, NOS - Female, 48 - Tissue image [1160630015014811]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Endometrioid adenocarcinoma, NOS - Female, 48 - Tissue image [1160630015015021]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Endometrioid adenocarcinoma, NOS - Female, 48 - Tissue image [1160630015017331]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Endometrioid adenocarcinoma, NOS - Female, 48 - Tissue image [116063001501251]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell adenocarcinoma, NOS - Female, 73 - Tissue image [9270729565559791]

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  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Endometrioid adenocarcinoma, NOS - Female, 48 - Tissue image [1160630015012621]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Squamous cell carcinoma, NOS - Female, 71 - Tissue image [3280730025624641]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell adenocarcinoma, NOS - Female, 73 - Tissue image [9270729565555851]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell adenocarcinoma, NOS - Female, 73 - Tissue image [9270729565556101]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell adenocarcinoma, NOS - Female, 73 - Tissue image [9270729565557501]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell adenocarcinoma, NOS - Female, 73 - Tissue image [9270729565551861]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021718851]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021713231]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021717841]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021717181]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021713781]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021718261]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021717391]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021713771]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Mullerian mixed tumor - Female, 60 - Tissue image [5280730021716701]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CORPUS UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Squamous cell carcinoma, NOS - Female, 71 - Tissue image [328073002562901]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Chondroid chordoma - Female, 56 - Tissue image [6270730022332791]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of NASOPHARYNX tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Chondroid chordoma - Female, 56 - Tissue image [6270730022338271]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of NASOPHARYNX tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Chondroid chordoma - Female, 56 - Tissue image [6270730022336571]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of NASOPHARYNX tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Chondroid chordoma - Female, 56 - Tissue image [6270730022339951]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of NASOPHARYNX tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [527073002343701]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [7040247104953231]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [5270730023436541]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [5270730023436201]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [5270730023435181]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Astrocytoma, anaplastic, IDH-mutant - Male, 60 - Tissue image [5270730023437631]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Squamous cell carcinoma, NOS - Female, 71 - Tissue image [3280730025626161]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells

  Publication

  • J. Węsierska-Gądek
  • N. Zulehner
  • F. Ferk
  • A. Składanowski
  • O. Komina
  • M. Maurer

  - BIOCHEMICAL PHARMACOLOGY - Year 2012

  Two cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability.Approximately 5-10% of breast and ovarian cancers result from inherited alterations or mutations in these genes.Remarkably, BRCA1/BRCA2-deficient cells are hypersensitive to selective inhibition of poly(ADPribose) polymerase 1 (PARP-1),...

  Full text available to download

• Glioma, NOS - Unknown, 31 - Tissue image [3280730025622301]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade serous carcinoma - Female, 67 - Tissue image [3300730069447601]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• High grade serous carcinoma - Female, 67 - Tissue image [10040729541214311]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of OVARY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, NOS - Unknown, 31 - Tissue image [3280730025625391]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Glioma, NOS - Unknown, 31 - Tissue image [328073002562621]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of BRAIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.