Search results for: BIOMIMETIC CHROMATOGRAPHY

• Thermodynamic study of new antiepileptic compounds by combining chromatography on the phosphatidylcholine biomimetic stationary phase and differential scanning calorimetry

  Publication

  • J. Flieger
  • H. Trębacz
  • M. Pizoń
  • A. Plazińska
  • W. Plaziński
  • A. Kowalska
  • A. Szczęsna
  • T. Plech

  - JOURNAL OF SEPARATION SCIENCE - Year 2019

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• Modification of gradient HPLC method for determination of small molecules' affinity to human serum albumin under column safety conditions: Robustness and chemometrics study

  Publication

  • M. Woziński
  • K. Greber
  • M. Pastewska
  • P. Kolasiński
  • W. Hewelt-Belka
  • B. Żołnowska
  • J. Sławiński
  • D. Szulczyk
  • W. Sawicki
  • K. Ciura

  - JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS - Year 2024

  In the early stages of drug discovery, beyond the biological activity screening, determining the physicochemical properties that affect the distribution of molecules in the human body is an essential step. Plasma protein binding (PPB) is one of the most important investigated endpoints. Nevertheless, the methodology for measuring %PPB is significantly less popular and standardized than other physicochemical properties, like lipophilicity....

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