Search results for: DOX-LOADED PNIPA-BISS MICROGELS

• Stable and degradable microgels linked with cystine for storing and environmentally triggered release of drugs

  Publication

  • M. Mackiewicz
  • K. Kaniewska
  • J. Romanski
  • E. Augustin
  • Z. Stojek
  • M. Karbarz

  - Journal of Materials Chemistry B - Year 2015

  Environmentally sensitive, degradable microgels based on poly(N-isopropylacrylamide) (pNIPA) crosslinked with the diacryloyl derivative of cystine (BISS) were synthesized by applying surfactant-free emulsion polymerization. pNIPA contributed the sensitivity to temperature to the microgels and the cross-linker made them degradable and sensitive to pH. The morphology of the microgels was investigated by using scanning and transmission...

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• Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases

  Publication

  • J. Biernat
  • E. Nazaruk
  • M. Godlewska

  - ELECTROCHIMICA ACTA - Year 2019

  Folate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...

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