Search results for: FILAGGRIN

• Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency

  Publication

  • A. Kobiela
  • W. Hewelt-Belka
  • J. Frackowiak
  • N. Kordulewska
  • L. Hovhannisyan
  • A. Bogucka
  • R. Etherington
  • A. Piróg
  • I. Dapic
  • S. Gabrielsson... and 3 others

  - Frontiers in Immunology - Year 2024

  Introduction: Exosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including in the skin. Atopic dermatitis (AD) is a chronic inflammatory skin disease for which filaggrin (FLG) gene mutations are the strongest genetic risk factor. Filaggrin insufficiency affects multiple cellular function, but it is unclear if sEV-mediated cellular communication...

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• O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation

  Publication

  • A. Kobiela
  • W. Hewelt-Belka
  • J. Frackowiak
  • N. Kordulewska
  • L. Hovhannisyan
  • A. Bogucka
  • R. Etherington
  • A. Pirog
  • I. Dapic
  • S. Gabrielsson... and 3 others

  - BRITISH JOURNAL OF DERMATOLOGY - Year 2023

  The association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function; the mutations are also linked to additional allergic manifestations, but it is unknown how the skin may influence inflammation in distant tissues. Here we investigated the impact of filaggrin insufficiency on keratinocyte-derived exosome-enriched small extracellular...

  Full text to download in external service