Search results for: INVERSE AGONIST - Bridge of Knowledge

Search results for: INVERSE AGONIST

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(4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl)Methanone Hydrochloride (LDK1229): A New Cannabinoid CB1 Receptor Inverse Agonist from the Class of Benzhydryl Piperazine Analogs
Publication
- M. M. Mahmoud
- T. Olszewska
- H. Liu
- D. M. Shore
- D. P. Hurst
- P. H. Reggio
- D. Lu
- D. A. Kendall
- MOLECULAR PHARMACOLOGY - Year 2015
Some inverse agonists of cannabinoid receptor type 1 (CB1) have been demonstrated to be anorectic antiobesity drug candidates. However, the first generation of CB1 inverse agonists, represented by rimonabant (SR141716A), otenabant, and taranabant, are centrally active, with a high level of psychiatric side effects. Hence, the discovery of CB1 inverse agonists with a chemical scaffold distinct from these holds promise for developing...

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