Search results for: IVABRADINE

• Forced Degradation Studies of Ivabradine and In Silico Toxicology Predictions for Its New Designated Impurities

  Publication

  • P. Pikul
  • M. Jamrógiewicz
  • J. Nowakowska
  • W. Hewelt-Belka
  • K. Ciura

  - Frontiers in Pharmacology - Year 2016

  All activities should aim to eliminate genotoxic impurities and/or protect the API against degradation. There is a necessity to monitor impurities from all classification groups, hence ivabradine forced degradation studies were performed. Ivabradine was proved to be quite durable active substance, but still new and with insufficient stability data. Increased temperature, acid, base, oxidation reagents and light were found to cause...

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• Forced degradation studies of ivabradine and in silico toxicology predictions for its new designated impurities

  Publication

  • M. Jamrógiewicz
  • P. Pikul
  • J. Nowakowska
  • W. Hewelt-Belka
  • K. Ciura

  - Frontiers in Pharmacology - Year 2016

  All activities should aim to eliminate genotoxic impurities and/or protect the API againstdegradation. There is a necessity to monitor impurities from all classification groups,hence ivabradine forced degradation studies were performed. Ivabradine was provedto be quite durable active substance, but still new and with insufficient stability data.Increased temperature, acid, base, oxidation reagents and...