Search results for: MULTITARGETING AGENTS

• Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade

  Publication

  • M. Daśko
  • S. Demkowicz
  • K. Biernacki
  • O. Ciupak
  • W. Kozak
  • M. Masłyk
  • J. Rachoń

  - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY - Year 2020

  The purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulfatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and, therefore, represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. The inhibition of STS may effectively reduce the availability...

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