Search results for: NEURONAL PROTEOSTASIS

• Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models

  Publication

  • E. S. Chocron
  • E. Munkácsy
  • H. S. Kim
  • P. Karpowicz
  • N. Jiang
  • C. E. Van Skike
  • N. DeRosa
  • A. Q. Banh
  • J. P. Palavicini
  • P. Wityk... and 6 others

  - Science Advances - Year 2022

  The proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...

  Full text available to download

• Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models

  Publication

  • P. Wityk
  • E. S. Chocron
  • E. Munkácsy
  • H. S. Kim
  • P. Karpowicz
  • N. Jiang
  • V. S. E. Candice
  • N. DeRosa
  • B. Q. Andy
  • P. P. Juan... and 6 others

  - Science Advances - Year 2022

  The proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...

  Full text available to download