Search results for: OPIPRAMOL BASE

• Improvement of opipramol base solubility by complexation with β-cyclodextrin

  Publication

  • K. Hemine
  • A. Skwierawska
  • B. Kamińska
  • M. Prześniak-Welenc

  - SUPRAMOLECULAR CHEMISTRY - Year 2018

  Opipramol (OPI), a tricyclic antidepressant and anxiolytic compound, is administered orally in the form of a dihydrochloride. Salt form of the drug has a higher solubility in water and hence bioavailability and stability. A similar effect can be achieved by closing the hydrophobic part of the drug molecule in the cyclodextrin cavity. The paper presents opipramol inclusion complexes with beta-cyclodextrin (β-CD) in 1:1 molar ratio....

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