Search results for: P4503A4 ISOENZYME - Bridge of Knowledge

Search results for: P4503A4 ISOENZYME

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Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs’ Cytotoxicity, Metabolism and Cellular Response
Publication
- M. Pawłowska
- A. Kwaśniewska
- Z. Mazerska
- E. Augustin
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2020
Activity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced by them. As a result, drug-drug interactions can be modified. Acridinone derivatives, represented here by C-1305 and C-1311, are potent anticancer drugs. Previous studies in non-cellular systems showed that they are mechanism-based inhibitors of cytochrome P4503A4 and undergo glucuronidation via UDP-glucuronosyltranspherase...

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