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Early Stages of RNA-Mediated Conversion of Human Prions
Publication
- E. Lubecka
- U. H. E. Hansmann
- JOURNAL OF PHYSICAL CHEMISTRY B - Year 2022
Prion diseases are characterized by the conversion of prion proteins from a PrPC fold into a disease-causing PrPSC form that is self-replicating. A possible agent to trigger this conversion is polyadenosine RNA, but both mechanism and pathways of the conversion are poorly understood. Using coarse-grained molecular dynamic simulations we study the time evolution of PrPC over 600 μs. We find that both the D178N mutation and interacting...

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