Search results for: PRIONS - Bridge of Knowledge

Search

Search results for: PRIONS

Search results for: PRIONS

  • Early Stages of RNA-Mediated Conversion of Human Prions

    Publication

    - JOURNAL OF PHYSICAL CHEMISTRY B - Year 2022

    Prion diseases are characterized by the conversion of prion proteins from a PrPC fold into a disease-causing PrPSC form that is self-replicating. A possible agent to trigger this conversion is polyadenosine RNA, but both mechanism and pathways of the conversion are poorly understood. Using coarse-grained molecular dynamic simulations we study the time evolution of PrPC over 600 μs. We find that both the D178N mutation and interacting...

    Full text available to download