Early Stages of RNA-Mediated Conversion of Human Prions

Emilia Lubecka; Ulrich H. E. Hansmann

doi:10.1021/acs.jpcb.2c04614

Early Stages of RNA-Mediated Conversion of Human Prions

Abstract

Prion diseases are characterized by the conversion of prion proteins from a PrPC fold into a disease-causing PrPSC form that is self-replicating. A possible agent to trigger this conversion is polyadenosine RNA, but both mechanism and pathways of the conversion are poorly understood. Using coarse-grained molecular dynamic simulations we study the time evolution of PrPC over 600 μs. We find that both the D178N mutation and interacting with polyadenosine RNA reduce the helicity of the protein and encourage formation of segments with strand-like motifs. We conjecture that these transient β-strands nucleate the conversion of the protein to the scrapie conformation PrPSC.

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Authors (2)

Emilia Lubecka dr hab. inż.
Ulrich H. E. Hansmann

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Publication version: Accepted or Published Version
DOI:: Digital Object Identifier (open in new tab) 10.1021/acs.jpcb.2c04614
License: Copyright (2022 American Chemical Society)

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Articles

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artykuły w czasopismach

Published in:

JOURNAL OF PHYSICAL CHEMISTRY B no. 126, pages 6221 - 6230,
ISSN: 1520-6106

Language:

English

Publication year:

2022

Bibliographic description:

Lubecka E., Hansmann U. H. E.: Early Stages of RNA-Mediated Conversion of Human Prions// JOURNAL OF PHYSICAL CHEMISTRY B -Vol. 126,iss. 33 (2022), s.6221-6230

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