Search results for: bortezomib

• Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound

  Publication

  • K. Łuczkowska
  • K. E. Sokołowska
  • O. Taryma-Leśniak
  • K. Pastuszak
  • A. Supernat
  • J. Bybjerg-Grauholm
  • L. L. Hansen
  • E. Paczkowska
  • T. K. Wojdacz
  • B. Machaliński

  - Scientific Reports - Year 2021

  The anticancer activity of bortezomib (BTZ) has been increasingly studied in a number of indications and promising results for the use of this treatment have been shown in neuroblastoma. As BTZ treatment is usually administered in cycles, the development of resistance and side effects in patients undergoing therapy with BTZ remains a major challenge for the clinical usage of this compound. Common resistance development also means...

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• The Value of Serum MicroRNA Expression Signature in Predicting Refractoriness to Bortezomib-Based Therapy in Multiple Myeloma Patients

  Publication

  • P. Robak
  • I. Dróżdż
  • D. Jarych
  • D. Mikulski
  • E. Węgłowska
  • M. Siemieniuk-Ryś
  • M. Misiewicz
  • K. Stawiski
  • W. Fendler
  • J. Szemraj... and 2 others

  - Cancers - Year 2020

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• The Prognostic Value of Whole-Blood PSMB5, CXCR4, POMP, and RPL5 mRNA Expression in Patients with Multiple Myeloma Treated with Bortezomib

  Publication

  • P. Robak
  • D. Jarych
  • D. Mikulski
  • I. Dróżdż
  • E. Węgłowska
  • A. Kotkowska
  • M. Misiewicz
  • P. Smolewski
  • K. Stawiski
  • W. Fendler... and 2 others

  - Cancers - Year 2021

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• The Prognostic Value of Whole-Blood PSMB5, CXCR4, POMP and RPL5 mRNA Expression in Patients with Multiple Myeloma Treated with Bortezomib

  Publication

  • P. Robak
  • D. Jarych
  • D. Mikulski
  • I. Dróżdż
  • E. Węgłowska
  • A. Kotkowska
  • M. Misiewicz
  • P. Smolewski
  • K. Stawiski
  • W. Fendler... and 2 others

  - Year 2021

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• Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells

  Publication

  • J. Lica
  • M. Wieczór
  • G. J. Grabe
  • M. Heldt
  • M. Jancz
  • M. Misiak
  • K. Gucwa
  • W. Brankiewicz
  • N. Maciejewska
  • A. Stupak... and 4 others

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2021

  Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...

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• Krzysztof Pastuszak mgr inż.

  People

  Department of Algorithms and Systems Modelling