Search results for: candicicin a3

• The complete stereochemistry of the antibiotic candicidin A3 (syn. ascosin A3, levorin A3)

  Publication

  • J. Borzyszkowska-Bukowska
  • P. Szczeblewski
  • A. Konkol
  • J. Grynda
  • K. Szwarc-Karabyka
  • T. Laskowski

  - NATURAL PRODUCT RESEARCH - Year 2019

  Herein, the stereostructure of the aromatic heptaene macrolide (AHM) antifungal antibiotic candicidin A3 (syn. ascosin A3, levorin A3) has been established upon the 2D NMR studies, consisting of DQF-COSY, TOCSY, ROESY, HSQC and HMBC experiments, as well as upon extensive molecular dynamics simulations. The geometry of the heptaenic chromophore was defined as: (22E, 24E, 26Z, 28Z, 30E, 32E, 34E). The previously unreported absolute...

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