Search results for: epigenetic remodelling

• Transcriptional activity of epigenetic remodeling genes declines in keratinocytes after in vitro expansion

  Publication

  • J. Kamińska
  • P. Langa
  • M. Deptuła
  • J. Zieliński
  • P. Sachadyn
  • A. Wardowska
  • M. Pikuła

  - Advances in Medical Sciences - Year 2019

  PURPOSE: In vitro expansion is an invaluable method to obtain keratinocytes in amounts necessary for effective transplantation therapies. In vitro cell culturing provokes questions concerning potential epigenetic alterations occurring in expanded cells in the context of usefulness for transplantation and safety. The purpose of this study was to investigate as to whether keratinocyte expansion is associated with changes in the activity...

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