Search results for: liver cell microsomes

• Detoxification of the tricyclic antidepressant opipramol and its analog – IS-noh by UGT enzymes before and after activation by phase I enzymes in rat liver microsomes

  Publication

  • A. Mieszkowska
  • K. Hemine
  • A. Skwierawska
  • E. Augustin
  • Z. Mazerska

  - CHEMICAL PAPERS - Year 2021

  The present studies were carried out to evaluate the simultaneous one-pot metabolism of opipramol (IS-opi) and analog (IS-noh) by phase I and phase II enzymes present in rat liver microsomes (RLM) as an alternative to separate testing with recombinant enzymes. This approach allows for more time-saving and cost-effective screening of the metabolism of newly discovered drugs. We also considered that the lack of results for phase...

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• Flavin monooxygenases, FMO1 and FMO3, not cytochrome p450 isoenzymes, contribute to metabolism of anti-tumour triazoloacridinone, C-1305, in liver microsomes and HepG2 cells.

  Publication

  • B. Fedejko-Kap
  • M. Niemira
  • A. Radomińska-Pandya
  • Z. Mazerska

  - XENOBIOTICA - Year 2011

  Celem pracy było określenie roli wybranych enzymów frakcji mikrosomalnej komórek wątroby w metabolizmie pochodnej triazoloakrydonu, związku C-1305. Wykazano, że badana pochodna ulega transformacji wobec frakcji enzymów izolowanych z hepatocytów szczurzych i ludzkich oraz jest metabolizowana przez komórki linii HepG2. Badania wykazały ponadto, że enzymami odpowiedzialnymi za obserwowane przemiany były monooksygenazy flawinowe, FMO1...

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• In vitro enzyme kinetics and NMR-based product elucidation for glutathione S-conjugation of the anticancer unsymmetrical bisacridine C-2028 in liver microsomes and cytosol: major role of glutathione S-transferase M1-1 isoenzyme

  Publication

  • A. Potęga
  • D. Rafalska
  • D. Kazimierczyk
  • M. Kosno
  • A. Pawłowicz
  • W. Andrałojć
  • E. Paluszkiewicz
  • T. Laskowski

  - MOLECULES - Year 2023

  This work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione S-transferase/glutathione (GST/GSH) system. Here, we analyzed the concentration- and pH-dependent GSH conjugation of C-2028 in rat liver microsomes and cytosol. We also applied three recombinant human GST isoenzymes, which altered expression was found in various tumors. The...

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• N-doped carbon nanospheres as selective fluorescent probes for mercury detection in contaminated aqueous media: chemistry, fluorescence probing, cell line patterning, and liver tissue interaction

  Publication

  • S. Sojdeh
  • A. Banitalebi Dehkordi
  • A. Badiei
  • A. Zarrabi
  • P. Makvandi
  • M. Ashrafizadeh
  • M. Saeb
  • E. C. Lima
  • M. Rabiee
  • M. Asadnia... and 2 others

  - ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH - Year 2023

  A precise nano-scale biosensor was developed here to detect Hg2+ in aqueous media. Nitrogen-doped carbon nanospheres (NCS) created from the pyrolysis of melamine–formaldehyde resin were characterized by FESEM, XRD, Raman spectra, EDS, PL, UV–vis spectra, and N2 adsorption–desorption, and were used as a highly selective and sensitive probe for detecting Hg2+ in aqueous media. The sensitivity of NCS to Hg2+ was evaluated by photoluminescence...

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• <p>Mechano-signalling, induced by fullerene C₆₀ nanofilms, arrests the cell cycle in the G2/M phase and decreases proliferation of liver cancer cells</p>

  Publication

  • M. Sosnowska
  • M. Kutwin
  • S. Jaworski
  • B. Strojny
  • M. Wierzbicki
  • J. Szczepaniak
  • M. Łojkowski
  • W. Święszkowski
  • J. Bałaban
  • A. Chwalibog
  • E. Sawosz

  - International Journal of Nanomedicine - Year 2019

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• Liver cell carcinoma - Male, 8 - Tissue image [9070730015337911]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015332931]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015338641]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015336441]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015339081]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015333131]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015331851]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [907073001533791]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015336611]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015329981]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [907073001532361]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015327201]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015328381]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015332591]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015324231]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [3300730069473991]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015324461]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015331401]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [907073001532471]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015334331]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015329601]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015327451]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015321921]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015324011]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015338501]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015331141]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015334481]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015339971]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015325181]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015338731]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015322921]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [90707300153221]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015329561]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [907073001532401]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [330073006947971]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015337531]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015327211]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015333071]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015335761]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015339361]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015321801]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015336861]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015339121]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015326581]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Liver cell carcinoma - Male, 8 - Tissue image [9070730015329861]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of LIVER AND INTRAHEPATIC BILE DUCTS tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.