Search results for: optical tweezers

• Brownian Motion in Optical Tweezers, a Comparison between MD Simulations and Experimental Data in the Ballistic Regime

  Publication

  • K. Zembrzycki
  • S. Pawłowska
  • F. Pierini
  • T. A. Kowalewski

  - Polymers - Year 2023

  The four most popular water models in molecular dynamics were studied in large-scale simulations of Brownian motion of colloidal particles in optical tweezers and then compared with experimental measurements in the same time scale. We present the most direct comparison of colloidal polystyrene particle diffusion in molecular dynamics simulations and experimental data on the same time scales in the ballistic regime. The four most...

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• Methods for Elucidation of DNA-Anticancer Drug Interactions and Their Applications in the Development of New Drugs

  Publication

  • M. Misiak
  • F. Mantegazza
  • G. Beretta

  - CURRENT PHARMACEUTICAL DESIGN - Year 2016

  DNA damaging agents including anthracyclines, camptothecins and platinum drugs are among most frequently used drugs in the chemotherapeutic routine. Due to their relatively low selectivity for cancer cells, administration is associated with adverse side effects, whereas the inherent genotoxicity of these drugs is associated with risk of developing secondary cancers. Development of new drugs, which could be spared of these drawbacks...

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