Search results for: patch-clamp

• Self-assembly, stability and conductance of amphotericin B channels: bridging the gap between structure and function

  Publication

  • J. Zielińska
  • M. Wieczór
  • P. Chodnicki
  • E. Grela
  • R. Luchowski
  • Ł. Nierzwicki
  • T. Bączek
  • W. I. Gruszecki
  • J. Czub

  - NANOSCALE - Year 2021

  Amphotericin B (AmB), one of the most powerful but also toxic drugs used to treat systemic mycoses, is believed to selectively permeabilize fungal cell membranes to ions in a sterol-dependent manner. Unfortunately, the structure of the biologically active AmB channels has long eluded researchers, obstructing the design of safer alternatives. Here, we investigate the structural and thermodynamic aspects of channel formation, stability,...

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• Conserved motifs of MutL proteins

  Publication

  • M. Banasik
  • P. Sachadyn

  - MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS - Year 2014

  tThe MutL protein is best known for its function in DNA mismatch repair (MMR). However, there isevidence to suggest that MutL is not only the linker connecting the functions of MutS and MutH in MMR,but that it also participates in other repair systems, such as Very Short Patch (VSP), Base Excision (BER)and Nucleotide Excision Repair (NER). This study set out to identify the most highly conserved aminoacid sequence motifs in MutL...

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• Oleg Gradov senior researcher

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