Search results for: transcriptomic profiling

• Transcriptomic profiling of the salt stress response in excised leaves of the halophyte Beta vulgaris ssp. maritima

  Publication

  • M. Skorupa
  • M. Gołębiewski
  • K. Domagalski
  • K. Kurnik
  • K. Abu
  • M. Złoch
  • A. Tretyn
  • J. Tyburski

  - Plant Science - Year 2016

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• Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization

  Publication

  • J. Króliczewski,
  • S. Bartoszewska
  • M. Dudkowska
  • D. Janiszewska
  • A. Biernatowska
  • D. Crossman
  • K. Krzymiński
  • M. Wysocka
  • A. Romanowska
  • M. Bagiński... and 6 others

  - Cancers - Year 2020

  Rational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...

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• Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse

  Publication

  • J. Podolak-Popinigis
  • B. Górnikiewicz
  • A. Ronowicz
  • P. Sachadyn

  - BMC GENOMICS - Year 2015

  Background: The MRL/MpJ mouse is a laboratory inbred strain known for regenerative abilities which are manifested by scarless closure of ear pinna punch holes. Enhanced healing responses have been reported in other organs. A remarkable feature of the strain is that the adult MRL/MpJ mouse retains several embryonic biochemical characteristics, including increased expression of stem cell markers. Results: We explored the transcriptome...

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• Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells

  Publication

  • M. Niemira
  • B. Borowa-Mazgaj
  • S. B. Bader
  • A. Moszyńska
  • M. Ratajewski
  • K. Karaś
  • M. Kwaśniewski
  • A. Krętowski
  • Z. Mazerska
  • E. M. Hammond
  • A. Skwarska

  - Biomedicines - Year 2020

  Androgen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...

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