Search results for: DIHYDROXYCHOLESTEROL

• Accelerated remyelination and immune modulation by the EBI2 agonist 7α,25-dihydroxycholesterol analogue in the cuprizone model

  Publication

  • K. Konieczna-Wolska
  • F. Caratis
  • M. Opiełka
  • K. Biernacki
  • K. Urbanowicz
  • J. Klimaszewska
  • P. Pobiarzyn
  • O. Krajewski
  • S. Demkowicz
  • R. T. Smoleński... and 3 others

  - BIOMEDICINE & PHARMACOTHERAPY - Year 2024

  Research indicates a role for EBI2 receptor in remyelination, demonstrating that its deficiency or antagonism inhibits this process. However, activation of EBI2 with its endogenous ligand, oxysterol 7α,25-dihydroxycholesterol (7α,25OHC), does not enhance remyelination beyond the levels observed in spontaneously remyelinating tissue. We hypothesized that the short half-life of the natural ligand might explain this lack of beneficial...

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• The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers

  Publication

  • M. Chalubinski
  • K. Zemanek
  • W. Skowron
  • K. Wojdan
  • P. Gorzelak
  • M. Broncel

  - INFLAMMATION RESEARCH - Year 2013

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