Search results for: NEOANTIGENS

• O07 Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation

  Publication

  • A. Kobiela
  • W. Hewelt-Belka
  • J. Frackowiak
  • N. Kordulewska
  • L. Hovhannisyan
  • A. Bogucka
  • R. Etherington
  • A. Pirog
  • I. Dapic
  • S. Gabrielsson... and 3 others

  - BRITISH JOURNAL OF DERMATOLOGY - Year 2023

  The association between FLG loss-of-function mutations and the development of atopic dermatitis (AD) indicates that filaggrin is critical to skin barrier function; the mutations are also linked to additional allergic manifestations, but it is unknown how the skin may influence inflammation in distant tissues. Here we investigated the impact of filaggrin insufficiency on keratinocyte-derived exosome-enriched small extracellular...

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