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Search results for: ppgis
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Identification of Substrates of Cytoplasmic Peptidyl-Prolyl Cis/Trans Isomerases and Their Collective Essentiality in Escherichia Coli
PublicationProtein folding often requires molecular chaperones and folding catalysts, such as peptidyl-prolyl cis/trans isomerases (PPIs). The Escherichia coli cytoplasm contains six well-known PPIs, although a requirement of their PPIase activity, the identity of their substrates and relative enzymatic contribution is unknown. Thus, strains lacking all periplasmic and one of the cytoplasmic PPIs were constructed. Measurement of their PPIase...
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Multicopy Suppressor Analysis of Strains Lacking Cytoplasmic Peptidyl-Prolyl cis/trans Isomerases Identifies Three New PPIase Activities in Escherichia coli That Includes the DksA Transcription Factor
PublicationConsistent with a role in catalyzing rate-limiting step of protein folding, removal of genes encoding cytoplasmic protein folding catalysts belonging to the family of peptidyl-prolyl cis/trans isomerases (PPIs) in Escherichia coli confers conditional lethality. To address the molecular basis of the essentiality of PPIs, a multicopy suppressor approach revealed that overexpression of genes encoding chaperones (DnaK/J and GroL/S),...
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Ocena warunków nasłonecznienia i projektowanie elektrowni słonecznych z wykorzystaniem dedykowanego oprogramowania oraz baz danych
PublicationPrzytoczono typowe dla obszaru Polski wartości nasłonecznienia. Zaprezentowano sposoby dokładniejszego określenia wartości nasłonecznienia w oparciu o bazy danych o nasłonecznieniu i aplikacje komputerowe. Narzędzia te pozwalają w pełniejszy sposób uwzględnić kąt nachylenia i azymut modułów fotowoltaicznych, linię horyzontu i zacienienie oraz zmienność nasłonecznienia w ciągu roku na podstawie statystycznych wartości nasłonecznia...
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Ahmer Bin Hafeez
PeopleI have experience in Microbiology & Computational Biology, particularly bioinformatics, homology modeling, phylogenetics, structural biology, and drug discovery. Currently, my interest lies in translatable omics studies and drug discovery against novel protein targets involved in cancer and infectious diseases and Host-Pathogen PPIs. My aim involves the use of computational methods for the identification of novel targets and to...