Year 2016

• Intramolecular transformation of an antifungal antibiotic nystatin A1 into its isomer, iso-nystatin A1 - structural and molecular modeling studies

  Publication

  • K. Szwarc-Karabyka
  • M. Płosiński
  • K. Czerniejewska
  • T. Laskowski
  • A. Leniak
  • J. Czub
  • P. Kubica
  • P. Sowiński
  • J. Pawlak
  • E. Borowski

  - MAGNETIC RESONANCE IN CHEMISTRY - Year 2016

  Nystatin A1, a polyene macrolide antifungal antibiotic, in a slightly basic or acidic solution undergoes an intramolecular transformation, yielding a structural isomer, the translactonization product, iso-nystatin A1 with lactone ring diminished by two carbon atoms. Structural evidence is provided by advanced NMR and Mass Spectrometry (MS) studies. Molecular dynamics simulations and quantum mechanics calculations gave the insight...

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