Intramolecular transformation of an antifungal antibiotic nystatin A1 into its isomer, iso-nystatin A1 - structural and molecular modeling studies - Publication - Bridge of Knowledge

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Intramolecular transformation of an antifungal antibiotic nystatin A1 into its isomer, iso-nystatin A1 - structural and molecular modeling studies

Abstract

Nystatin A1, a polyene macrolide antifungal antibiotic, in a slightly basic or acidic solution undergoes an intramolecular transformation, yielding a structural isomer, the translactonization product, iso-nystatin A1 with lactone ring diminished by two carbon atoms. Structural evidence is provided by advanced NMR and Mass Spectrometry (MS) studies. Molecular dynamics simulations and quantum mechanics calculations gave the insight into the course and mechanism of the transformation and its effect on the conformation of the subject molecule.

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Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
MAGNETIC RESONANCE IN CHEMISTRY no. 54, edition 12, pages 953 - 961,
ISSN: 0749-1581
Language:
English
Publication year:
2016
Bibliographic description:
Szwarc K., Płosiński M., Czerniejewska K., Laskowski T., Leniak A., Czub J., Kubica P., Sowiński P., Pawlak J., Borowski E.: Intramolecular transformation of an antifungal antibiotic nystatin A1 into its isomer, iso-nystatin A1 - structural and molecular modeling studies// MAGNETIC RESONANCE IN CHEMISTRY. -Vol. 54, iss. 12 (2016), s.953-961
DOI:
Digital Object Identifier (open in new tab) 10.1002/mrc.4478
Verified by:
Gdańsk University of Technology

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