Prof dr hab Adam Lesner
Employment
- 1995 - present professor at Chemistry
Publications
Filters
total: 116
Catalog Publications
Year 2013
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A new proteinase 3 substrate with improved selectivity over human neutrophil elastase
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Adrenal Secretory Protease
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Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus
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Hybrid analogues of SFTI-1 modified in P1 position by β- and γ-amino acids and N-substituted β-alanines
PublicationA series of compounds containing either non-proteinogenic beta-/gamma-amino acids or N-substituted beta-alanine residues (beta-peptoid units) in P-1 specificity position were synthesized based on the structure of sunflower trypsin inhibitor 1 (SFTI-1). The compounds were synthesized on a solid support; the N-substituted beta-alanines (beta Nhlys and beta Nhphe) were introduced into a peptidomimetic chain via a two-step approach...
Year 2018
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A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA
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Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia
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Conjugate of Enkephalin and Temporin Peptides as a Novel Therapeutic Agent for Sepsis
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Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
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Design, Synthesis, and Enzymatic Evaluation of Novel ZnO Quantum Dot-Based Assay for Detection of Proteinase 3 Activity
PublicationHerein, the synthesis and application of functionalized quantum dot-based protease probes is described. Such probes are composed of nontoxic ZnO nanocrystals decorated by amino groups followed by linker and labeled peptide attachment. Spherical NH2-terminated ZnO quantum dots (QDs) with the average size ranging from 4 to 8 nm and strong emission centered at 530 nm were prepared using the sol−gel method. The fluorescence of ZnO...
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Exploiting the S4–S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis
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Year 2020
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A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome
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Activity-based protein profiling guided identification of urine proteinase 3 activity in subclinical rejection after renal transplantation
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Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia
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Fecal Serine Protease Profiling in Inflammatory Bowel Diseases
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Human proteinase 3 resistance to inhibition extends to alpha‐2 macroglobulin
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Year 2004
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A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach
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Year 2019
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Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases
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Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity
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Year 2011
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Analogues of trypsin inhibitor SFTI-1 modified in the conserved P1′ position by synthetic or non-proteinogenic amino acids retain their inhibitory activity
PublicationA series of linear and monocyclic (with a disulfide bridge only) analogues of trypsin inhibitor SFTI-1 modified in the P-1 and/or P-1' positions were synthesized by the solid-phase method. In the substrate specificity P-1 position, Phe or N-benzylglycine (Nphe) were introduced, whereas the conserved Ser6 in Bownam-Birk (BBI) inhibitors was replaced by Hse (L-homoserine), Nhse [N-(2-hydroxyethyl)glycine], Sar, and Ala. Kinetic studies...
Year 2010
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Analogues of Trypsin Inhibitor SFTI-1 with Disulfide Bridge Substituted by Various Length of Carbonyl Bridges
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Highly Specific Substrates of Proteinase 3 Containing 3-(2-Benzoxazol-5-yl)-l-alanine and Their Application for Detection of This Enzyme in Human Serum
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Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases
PublicationFourteen monocyclic analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds were synthesized by the solid-phase method. The purpose of this work was to establish the role of a disulfide bridge present in inhibitor's side chains of Cys3 and Cys11 in association with serine proteinases. This cyclic fragment was replaced by the disulfide bridges formed by L-pencillamine (Pen), homo-L-cysteine (Hcy), N-sulfanylethylglycine...
Year 2015
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Analysis of the Link between the Redox State and Enzymatic Activity of the HtrA (DegP) Protein from Escherichia coli
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Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice
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Conformational studies of [Nphe5]SFTI-1 by means of 2D NMR spectroscopy in conjunction with molecular dynamics calculations
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Design and synthesis of new substrates of HtrA2 protease
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Year 2016
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Analysis of urinary cathepsin C for diagnosing Papillon–Lefèvre syndrome
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Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)
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Bladder cancer detection using a peptide substrate of the 20S proteasome
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Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples
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Year 2009
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Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells
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Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4+ T cells and has anti-viral activity
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Year 2022
Year 2014
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Cathepsin G activity lowers plasma LDL and reduces atherosclerosis
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Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor with tailored phosphonic inhibitor
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Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI-1
Publication
Year 2001
Year 2000
Year 2008
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Design of selective substrates of proteinase 3 using combinatorial chemistry methods
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Designing of Substrates and Inhibitors of Bovine α-Chymotrypsin with Synthetic Phenylalanine Analogues in Position P1
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Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods
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Year 2007
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Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI‐1 as a starting structure
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Inhibition of HIV‐1 or bacterial activation of macrophages by products of HIV‐1‐resistant human cells
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Year 2021
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Digestive Inflammation: Role of Proteolytic Dysregulation
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Elastolytic activity is associated with inflammation in bladder cancer
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Gut Serpinome: Emerging Evidence in IBD
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Year 1997
Year 2012
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Editorial(Hot Topic: Proteolysis in Health and Disease)
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Future of Protease Activity Assays
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Year 2002
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