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Dawid Kazimierczyk
Employment
Business contact
Centrum Transferu Wiedzy i Technologii
- Location
- Al. Zwycięstwa 27, 80-219 Gdańsk
- Phone
- +48 58 348 62 62
- biznes@pg.edu.pl
Contact
- s166007@student.pg.edu.pl
Publication showcase
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In vitro enzyme kinetics and NMR-based product elucidation for glutathione S-conjugation of the anticancer unsymmetrical bisacridine C-2028 in liver microsomes and cytosol: major role of glutathione S-transferase M1-1 isoenzyme
This work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione S-transferase/glutathione (GST/GSH) system. Here, we analyzed the concentration- and pH-dependent GSH conjugation of C-2028 in rat liver microsomes and cytosol. We also applied three recombinant human GST isoenzymes, which altered expression was found in various tumors. The...
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