Year 2021

• PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke

  Publication

  • J. Mazuryk
  • I. Puchalska
  • K. Koziński
  • M. J. Ślusarz
  • J. Ruczyński
  • P. Rekowski
  • P. Rogujski
  • R. Płatek
  • M. B. Wiśniewska
  • A. Piotrowski... and 7 others

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Year 2021

  Ischemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...

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Year 2019

• Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities

  Publication

  • N. Ptaszyńska
  • K. Gucwa
  • K. Olkiewicz
  • A. Łȩgowska
  • J. Okońska
  • J. Ruczyński
  • A. Gitlin-Domagalska
  • D. Dȩbowski
  • S. Milewski
  • K. Rolka

  - ACS Chemical Biology - Year 2019

  Recent studies have shown that modified human lactoferrin 20−31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to synthesize and evaluate the biological activity of a series of conjugates based on this peptide and one of the antimicrobials with proven antibacterial (ciprofloxacin, CIP, and levofloxacin, LVX) or antifungal (fluconazole, FLC) activity. The drugs were covalently connected...

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• Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse

  Publication

  • P. Sass
  • P. Sosnowski
  • J. Podolak-Popinigis
  • B. Górnikiewicz
  • J. Kamińska
  • M. Deptuła
  • E. Nowicka
  • A. Wardowska
  • J. Ruczyński
  • P. Rekowski... and 12 others

  - EBioMedicine - Year 2019

  Background:Most studies on regenerative medicine focus on cell-based therapies and transplantations.Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensivelyinvestigated in regenerative research. It is known that healing potential decreases with development and devel-opmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerativecapacity.Methods:We...

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