Year 2024

• Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations

  Publication

  • P. Kaźmierska-Grębowska
  • M. Jankowski
  • B. M. MacIver

  - Aging and Disease - Year 2024

  Increasing evidence indicates a role of hyperpolarization activated cation (HCN) channels in controlling the resting membrane potential, pacemaker activity, memory formation, sleep, and arousal. Their disfunction may be associated with the development of epilepsy and age-related memory decline. Neuronal hyperexcitability involved in epileptogenesis and EEG desynchronization occur in the course of dementia in human Alzheimer’s Disease...

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Year 2023

• An automated, low-latency environment for studying the neural basis of behavior in freely moving rats

  Publication

  • M. Jankowski
  • A. Polterovich
  • A. Kazakov
  • J. Niediek
  • I. Nelken

  - BMC BIOLOGY - Year 2023

  Background Behavior consists of the interaction between an organism and its environment, and is controlled by the brain. Brain activity varies at sub-second time scales, but behavioral measures are usually coarse (often consisting of only binary trial outcomes). Results To overcome this mismatch, we developed the Rat Interactive Foraging Facility (RIFF): a programmable interactive arena for freely moving rats with multiple feeding...

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