Marcin Ratajewski - Publications - Bridge of Knowledge

Marcin Ratajewski

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Year 2020

Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
Publication
- M. Niemira
- B. Borowa-Mazgaj
- S. B. Bader
- A. Moszyńska
- M. Ratajewski
- K. Karaś
- M. Kwaśniewski
- A. Krętowski
- Z. Mazerska
- E. M. Hammond
- A. Skwarska
- Biomedicines - Year 2020
Androgen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...

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