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Michał Beffinger
Employment
Business contact
Centrum Transferu Wiedzy i Technologii
- Location
- Al. Zwycięstwa 27, 80-219 Gdańsk
- Phone
- +48 58 348 62 62
- biznes@pg.edu.pl
Contact
- micbeffi@student.pg.edu.pl
Publication showcase
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Targeting of FLT3-ITD kinase contributes to high selectivity of imidazoacridinone C-1311 against FLT3-activated leukemia cells
Drugs targeting receptor tyrosine kinase FLT3 are of particular interest since activating FLT3-internal tandem duplication (ITD) mutations abundantly occur in fatal acute myeloid leukemias (AMLs). Imidazoacridinone C-1311, a DNA-reactive inhibitor of topoisomerase II, has been previously shown to be a potent and selective inhibitor of recombinant FLT3. Here, we expand those findings by studying its effect on leukemia cells with...
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The Role of FLT3 Kinase as an AML Therapy Target
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