iCovid, impedimetric platform based on boron-doped diamond nanostructures for quantitative analysis of virus-receptor interactions

The project concerns new impedance diagnostic techniques based on the analysis of the interaction of proteins derived from SARS-Co-2. Experimental research will be supported by quantum simulations. The result will be scientific publications and know-how. The employment of biotechnologists and cooperation with laboratories from the Jagiellonian University, IBMM and Caltech (USA) are planned.

Details

Project's acronym:

iCovid

Financial Program Name:

EXPRESS CALL TO FUND RESEARCH ON COVID-19

Organization:

Narodowe Centrum Nauki (NCN) (National Science Centre)

Agreement:

UMO-2020/01/0/ST7/00104 z dnia 2020-06-05

Realisation period:

2020-06-05 - 2021-12-04

Project manager:

dr hab. inż. Robert Bogdanowicz

Team members:

researcher dr hab. inż. Jacek Ryl

Realised in:

Faculty of Electronics, Telecommunications and Informatics

Project's value:

536 400.00 PLN

Request type:

National Research Programmes

Domestic:

Domestic project

Verified by:

Gdańsk University of Technology

Papers associated with that project

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total: 4

Year 2022

Enhanced susceptibility of SARS-CoV-2 spike RBD protein assay targeted by cellular receptors ACE2 and CD147: Multivariate data analysis of multisine impedimetric response
Publication
- M. Brodowski
- M. Pierpaoli
- M. Janik
- M. Kowalski
- M. Ficek
- P. Ślepski
- B. Trzaskowski
- G. N. Swain
- J. Ryl
- R. Bogdanowicz
- SENSORS AND ACTUATORS B-CHEMICAL - Year 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the cells through the binding of spike protein to the host cell surface-expressing angiotensin-converting enzyme 2 (ACE2) or by endocytosis mediated by extracellular matrix metalloproteinase inducer (CD147). We present extended statistical studies of the multisine dynamic electrochemical impedance spectroscopy (DEIS) revealing interactions between Spike RBD and...

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Performance of electrochemical immunoassays for clinical diagnostics of SARS-CoV-2 based on selective nucleocapsid N protein detection: Boron-doped diamond, gold and glassy carbon evaluation
Publication
- W. Białobrzeska
- M. Ficek
- B. Dec
- S. Osella
- B. Trzaskowski
- A. Jaramillo-Botero
- M. Pierpaoli
- M. Rycewicz
- Y. Dashkevich
- T. Łęga... and 15 others
- BIOSENSORS & BIOELECTRONICS - Year 2022
The 21st century has already brought us a plethora of new threats related to viruses that emerge in humans after zoonotic transmission or drastically change their geographic distribution or prevalence. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first spotted at the end of 2019 to rapidly spread in southwest Asia and later cause a global pandemic, which paralyzes the world since then. We have designed novel...

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Poly-L-Lysine-functionalized fluorescent diamond particles: pH triggered fluorescence enhancement via surface charge modulation
Publication
- M. Janik
- M. J. Głowacki (formerly: M. Głowacki)
- M. Sawczak
- A. Wcisło
- P. Niedziałkowski
- K. Jurak
- M. Ficek
- R. Bogdanowicz
- MRS BULLETIN - Year 2022
Recently, the interest in applying fluorescent diamond particles (FDPs) containing nitrogen-vacancy (NV) centers for enhancing the mechanical and chemical properties of some materials, biological imaging, and sensing has been expanding rapidly. The unique properties of NV centers such as intensive, time-stable fluorescence, and an electron spin, which exhibits long coherence time and may be manipulated using external stimuli, such...

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Year 2021

Nitrogen-Incorporated Boron-Doped Nanocrystalline Diamond Nanowires for Microplasma Illumination
Publication
- S. K. Sethy
- M. Ficek
- K. J. Sankaran
- S. Sain
- A. R. Tripathy
- S. Gupta
- J. Ryl
- S. Sinha Roy
- N. Tai
- R. Bogdanowicz
- ACS Applied Materials & Interfaces - Year 2021
The origin of nitrogen-incorporated boron-doped nanocrystalline diamond (NB-NCD) nanowires as a function of substrate temperature (Ts) in H2/CH4/B2H6/N2 reactant gases is systematically addressed. Because of Ts, there is a drastic modification in the dimensional structure and microstructure and hence in the several properties of the NB-NCD films. The NB-NCD films grown at low Ts (400 °C) contain faceted diamond grains. The morphology...

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