Cytotoxic and Antioxidant Activities of Benzohydroxamic Acid Analogues

Witold Przychodzeń

doi:10.5012/bkcs.2013.34.10.3098

Cytotoxic and Antioxidant Activities of Benzohydroxamic Acid Analogues

Abstract

20 benzohydroxamic acid analogues were synthesized and evaluated for their in vitro cytotoxicities against mouse mammary tumor cells as well as antioxidant activities against DPPH radical and superoxide anion. It was found that benzothiohydroxamic acids exhibit greater cytotoxicities than benzohydroxamic acids and N-isopropyl derivatives are more active than N-methyl ones. On the other hand, benzothiohydroxamic acids show more potent DPPH radical scavenging acitivities, but superoxide anion quenching ability is better for benzohydroxamic acids bearing electron-donating substituents.

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Authors (2)

Witold Przychodzeń dr hab. inż.
Jacek Nycz

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Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: BULLETIN OF THE KOREAN CHEMICAL SOCIETY no. 34, pages 3098 - 3100,
ISSN: 1229-5949
Language:: English
Publication year:: 2013
Bibliographic description:: Przychodzeń W.: Cytotoxic and Antioxidant Activities of Benzohydroxamic Acid Analogues// BULLETIN OF THE KOREAN CHEMICAL SOCIETY. -Vol. 34, nr. 10 (2013), s.3098-3100
DOI:: Digital Object Identifier (open in new tab) 10.5012/bkcs.2013.34.10.3098
Verified by:: Gdańsk University of Technology