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Design, synthesis, and molecular docking of new 5-HT reuptake inhibitors based on modified 1,2-dihydrocyclopenta[b] indol-3(4H)-one scaffold
Abstract
A new group of serotonin reuptake inhibitors containing 1,2-dihydrocyclopenta[b]indol-3(4H)-one scaffoldwas synthesized, starting from indole 5-((1H-indol-3-yl)(1,3-dioxane-4,6-diones as a key intermediates. Following three transformations including intramolecular cyclization and formation of imines, a series of new ligand for human serotonin transporter was obtained. The ability of these ligands to inhibit human TS3 serotonin transporter as well as selectivity toward human D3 dopamine receptor and dopamine transporter were tested in silico using docking software.
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- Copyright (2019 Indian Academy of Sciences)
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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JOURNAL OF CHEMICAL SCIENCES
no. 131,
pages 1 - 13,
ISSN: 0974-3626 - Language:
- English
- Publication year:
- 2019
- Bibliographic description:
- Szewczyk M., Punda P., Janikowska K., Makowiec S.: Design, synthesis, and molecular docking of new 5-HT reuptake inhibitors based on modified 1,2-dihydrocyclopenta[b] indol-3(4H)-one scaffold// JOURNAL OF CHEMICAL SCIENCES -Vol. 131,iss. 6 (2019), s.1-13
- DOI:
- Digital Object Identifier (open in new tab) 10.1007/s12039-019-1621-x
- Verified by:
- Gdańsk University of Technology
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